Histopathological description of ocular and nervous lesions in domestic rabbits infected with Encephalitozoon cuniculi: an overview

Authors

  • Daniel Barrantes-Murillo Universidad Nacional Escuela de Medicina Veterinaria Departamento de Patología, Costa Rica
  • Alejandro Alfaro-Alarcón Universidad Nacional Escuela de Medicina Veterinaria Departamento de Patología, Costa Rica

Keywords:

<i>Encephalitozoon cuniculi</i>, central nervous system, granulomatous encephalitis, phacoclastic uveitis

Abstract

This paper describes ocular and central nervous system lesions of rabbits infected with Encephalitozoon cuniculi. The histopathological analysis, together with the use of special Ziehl-Neelsen and Gomori methenamine silver stains, is the most sensitive post-mortem diagnostic test. The neurologic lesion affects most of these patients and is related to severe multifocal granulomatous encephalitis. In many cases, microsporidial spores can be observed with the help of special stains. Ocular lesions are less frequent than nervous ones; they are characterized by a bilateral or unilateral phacoclastic uveitis.

References

Aroch, I., Holmberg, B.J., Sutton, G.A. and B.P. Wilcock. 2008. Slatter´s Fundamentals of Veterinary Ophtalmology. Pages 71-72 in General Pathology of the Eye. 4th ed. Saunders Elsevier, USA.

Csokai, J., Joachim, A., Gruber, A., Tichy, A., Pakozdy, A. and F. Kunzel. 2009. Diagnostic markers for encephalitozoonosis en pet rabbits. Vet. Parasit. 163: 18-26.

Dubliezig, R.R, Ketring, K.L., G.J. Mclellan and D.M. Albert. 2010. Veterinary Ocular Pathology: a comparative review. Pages 266-267 in The Uvea. Elsevier, UK.

Garcia, L. 2002. Laboratory Identification if the Microsporidia. Journal if Clinical Microbiology. June, 1892-1901.

Grant, M. and S. Youssef. 2007. Pathology of domestic Animals. Pages 433-434 in Nervous system. 5Th ed. Elsevier, USA

Gruber, A., Pakozdy, A., Weissenbock, H., Csokai, J. and F. Kunzel. 2008. A Retrospective Study of Neurological Disease in 118 Rabbits. J. Comp. Path. 140: 31-37.

Harcourt-Brown, F. 2003. Textbook of Rabbit Medicine. Pages 304-305 in Ophtalmic Diseases. Science, UK.

Harcourt-Brown, F.M. 2004. Encephalitozoon cuniculi Infection in Rabbits. Seminars in Avian and Exotic Pet Medicine. 13: 86-93.

Jeklova, E., Jekl, V., Kovarcik, K., Hauptman, K., Koudela, B., Neumareyova, H., Knotek, Z. and M. Fladyna. 2009. Usefulnes of detection of specific IgM and IgG antibodies for diagnosis of clinical enceophalitozoonosis in pet rabbits. Vet. Parasit. 170: 143-148.

Keeble, E. J., and D.J. Shaw. 2006. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in the United Kingdom. Vet. Rec. 158: 539-544.

Kern, T.J. 1997. Rabbit and Rodent Ophthalmology. Seminars in Avian and Exotic Pet Medicine. 6: 138-145.

Künzel, F., Gruber, A., Tichy, A., Edelhofer, R., Nell, B., Hassan J., Leschnik, M., Thalhammer, J. G. and A. Joachim. 2008. Clinical symptoms and diagnosis of encephalitozoonosis in pet rabbits. Vet. Parasit. 151: 115-124.

Quesenberry, K.E., and J.W. Carpenter. 2012. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. Pages 246-247 in Neurologic and Musculoeskeletal Diseases. 3rd ed. Elsevier, USA.

Lonardi, C., Grilli, G., Ferrazi, V., Dal Cin, M., Rigolin, D. and A. Piccirillo. 2012. Serological survey of Encephalitozoon cuniculi infection in commercially reared rabbit does in Northern Italy. Res. Veter. Scien. 94: 295-298.

Müller, M. 1977. What are the microsporidia? Parasitology Today. 13: 455-456.

Oglesbee, B. 2011. Blacwell´s Five-Minute Veterinary Consult: Small Mammal. Pages 1023-1024 in Rabbits Anterior Uveitis. 2nd ed. Wiley-Blackwell, UK.

Ozkan, O., Ozkan, T. A. and K. Zafer. 2010. Encephalitozoonosis in New Zealand Rabbits and potential transmission risk. Vet. Parasit. 179: 234-237.

Rich, G. 2010. Clinical Update on Testing Modalities for Encephalitozoon cuniculi in clinically Sick Rabbits. J. of. Exot. Pet. Med. 19: 226-230.

Sieg, J., Hein, J., Jass, A., Sauter-Louis, C., Hartmann, K. and A. Fischer. 2011. Clinical evaluation of therapeutic success in rabbits with suspected encephalitozoonosis. Vet. Parasit. 187: 328-332.

Szabo J.R. and J.A. Shadduck. 1987. Experimental encephalitozoonosis in neonatal dogs. Veterinary Pathology. 24: 99-108.

Tee, K.Y., J.P. Kao, H.Y. Chiu, M.H. Chang, J.H. Wang, K.C. Tung, F.P. Cheng, and J.T. Wu. 2011. Serological survey for antibodies to Encephalitozoon cuniculi in rabbits in Taiwan. Vet. Parasit. 183:68-71.

Turner, S.M. 2010. Oftalmología de pequeños animales. Páginas 218-219 en Uveítis en Conejos. Elsevier, España.

Vandevelde, M., Higgins, R., Oevermann, A. 2012. Veterinary Neuropathology Essentials of Theory and Practice. Pages 68-69 in Inflammatory Diseases. Wiley-Blackwell.

Varga, M. 2014. Textbook of Rabbit Medicine. Pages 363-364 in Ophtalmic Diseases. 2nd ed. Butterworth-Heinemann Elsevier. London, UK.

Wagnerová, P., B. Sak, D. Kvetonová, M. Marsaleka, I. Langovác and M. Kvác. 2013. Humoral immune response and spreading of Encephalitozoon cuniculi infection in experimentally infected ponies. Vet. Parasit. 197:1-6.

Wagner, F. and M. Fehr. 2007. Common Ophthalmic Problems in Pet Rabbits. J of Ex. Pet. Med. 16: 158-167.

Wasson, K., and R.L. Pepper. 2000. Mammalian microsporidiosis. Veterinary Pathology. 37: 113-128.

Williams, D. 2012. Ophthalmology of Exotic Pets. Pages 46-47. The Rabbit Eye. Wiley-Blackwell, UK.

Wolfer, J., Grahan B., Wilcock, B., Percey, D. 1993. Phagoclastic uveítis in the rabbit. Progress in Veterinary and Comparative Ophthalmology. 3:92-97.

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Published

2015-08-03

How to Cite

Histopathological description of ocular and nervous lesions in domestic rabbits infected with Encephalitozoon cuniculi: an overview. (2015). Ciencias Veterinarias, 31(1), 27-36. https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/6823

How to Cite

Histopathological description of ocular and nervous lesions in domestic rabbits infected with Encephalitozoon cuniculi: an overview. (2015). Ciencias Veterinarias, 31(1), 27-36. https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/6823

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