Exercício aeróbico versus exercício simultâneo na interleucina-6 em pacientes com doença arterial coronária: Uma revisão sistemática
DOI:
https://doi.org/10.15359/mhs.19-1.5Palavras-chave:
Doença arterial coronária, aeróbica, concomitante, IL-6Resumo
O exercício aeróbio (EA) demonstrou beneficiar a sobrevivência dos pacientes com doença arterial coronária (DAC) e diminuir a interleucina 6 (IL-6). No entanto, há poucas evidências do efeito do treino simultâneo (TC). Objetivo: analisar o efeito da EA versus TC na IL-6 em pacientes com DAC. Metodologia: com base nos acordos PRISMA, foi realizada uma pesquisa de artigos científicos utilizando bases de dados eletrônicas. Os termos de busca (frase booleana) foram os seguintes: (''doença arterial coronária'' OU ''doença cardíaca'' OU ''doença cardiovascular'') E (''exercício'' OU ''treinamento'' OU ''reabilitação cardíaca'') E (''IL-6'' OU ''Interleucina-6'' OU ''marcadores inflamatórios''). As pesquisas foram realizadas entre agosto e dezembro de 2019. Resultados: Um total de 2516 estudos foram revistos, dos quais foram incluídos 10 estudos que preenchiam os critérios de elegibilidade. Foram analisados um total de 413 pacientes. A melhoria foi encontrada entre 5% e 74% com a EA e entre 2,3% e 58,8% com o TC. Ambas as modalidades diminuíram significativamente a IL-6, independentemente da idade, das sessões semanais de treinamento e do estágio inicial dos pacientes com DAC, mas os estudos que utilizaram alta intensidade ou volume superior a 30 minutos tiveram maiores benefícios. Conclusão: Tanto a EA como a TC são benéficas para a redução da IL-6 em pacientes com DAC. Esta revisão sistemática deixa espaço para uma investigação mais aprofundada sobre o comportamento de baixa intensidade da IL-6.
Referências
Akbarpour, M. (2013). The effect of aerobic training on serum adiponectin and leptin levels and inflammatory markers of coronary heart disease in obese men. Biology of Sport, 30(1), 21-27. https://dx.doi.org/10.5604%2F20831862.1029817
Alter, D., Oh, P., & Chong, A. (2009). Relationship between cardiac rehabilitation and survival after acute cardiac hospitalization within a universal health care system. European Journal of Cardiovascular Prevention and Rehabilitation, 16(1), 102-113. https://doi.org/10.1097/HJR.0b013e328325d662
Araya-Ramírez, F., Ureña-Bonilla, P., Sánchez-Ureña, B., Blanco-Romero, L., Rodríguez-Montero, A., & Moraga-Rojas, C. (2013). Influencia de la capacidad funcional inicial en marcadores fisiológicos después de un programa de rehabilitación cardiaca. Revista Costarricense de Cardiología, 15(1), 05-11. https://www.scielo.sa.cr/pdf/rcc/v15n1/art02v15n1.pdf
Beckie, T. M., Beckstead, J. W., & Groer, M. W. (2010). The Influence of Cardiac Rehabilitation on Inflammation and Metabolic Syndrome in Women with Coronary Heart Disease. The Journal of cardiovascular nursing, 25(1), 52-60. https://doi.org/10.1097/JCN.0b013e3181b7e500
Braith, R., Welsch, M., Feigenbaum, M., Kluess, H., & Pepine, C. (1999). Neuroendocrine activation in heart failure is modified by endurance exercise training. Journal of the American College of Cardiology, 34(4), 1170-1175. https://doi.org/10.1016/s0735-1097(99)00339-3
Buchan, D., Ollis, S., Young, J., Thomas, N., Cooper, S., Tong, T., Nie, J., Malina, R., & Baker, J. (2011). The effects of time and intensity of exercise on novel and established markers of CVD in adolescent youth. American Journal of Human Biology, 23(4), 517-526. https://doi.org/10.1002/ajhb.21166
Chow, S., Maisel, A., Anand, I., Bozkurt, B., de Boer, R., Felker, G., Fonarow, G., Greenberg, B., Januzzi, J., Kiernan, M., Liu, P., Wang, T., Yancy, C., & Zile, M. (2017). Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement from the American Heart Association. American Heart Association, 135(22), e1054-e1091. https://doi.org/10.1161/CIR.0000000000000490
Christodoulidis, G., Vittorio, T., Fudim, M., Lerakis, S., & Kosmas, C. E. (2014). Inflammation in coronary artery disease. Cardiology in Review, 22(6), 279-288. https://doi.org/10.1097/CRD.0000000000000006
Conraads, V., Beckers, P., Bosmans, J., De Clerck, L., Stevens, W., Vrints, C., & Brutsaert, D. (2002). Combined endurance/resistance training reduces plasma TNF-alpha receptor levels in patients with chronic heart failure and coronary artery disease. European Heart Journal, 23(23), 1854-1860. https://doi.org/10.1053/euhj.2002.3239
Crimi, E., Ignarro, L., Cacciatore, F., & Napoli, C. (2009). Mechanisms by which exercise training benefits patients with heart failure. Nature Reviews Ccardiology, 6(4), 292-300. https://doi.org/10.1038/nrcardio.2009.8
Del Giudice, M., & Gangestad, S. (2018). Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain, Behavior, and Immunity, 70, 61-75. https://doi.org/10.1016/j.bbi.2018.02.013
Dod, H., Bhardwaj, R., Sajja, V., Weidner, G., Hobbs, G. R., Konat, G. W., Manivannan, S., Gharib, W., Warden, B., Nanda, N., Beto, R., Ornish, D., & Jain, A. (2010). Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. The American Journal of Cardiology, 105(3), 362-367. https://doi.org/10.1016/j.amjcard.2009.09.038
Fioranelli, M., Bottaccioli, A., Bottaccioli, F., Bianchi, M., Rovesti, M., & Roccia, M. (2018). Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.02031
Fleg, J., Forman, D., Berra, K., Bittner, V., Blumenthal, J., Chen, M., Cheng, S., Kitzman, D., Maurer, M., Rich, M., Shen, W., Williams, M., & Zieman, S. (2013). Secondary prevention of atherosclerotic cardiovascular disease in older adults: A scientific statement from the American Heart Association. Circulation, 128(22), 2422-2446. https://doi.org/10.1161/01.cir.0000436752.99896.22
Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. (1999). Cytokine expression in advanced human atherosclerotic plaques: Dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis, 145(1), 33-43. https://doi.org/10.1016/s0021-9150(99)00011-8
Fu, T., Wang, C., Lin, P., Hsu, C., Cherng, W., Huang, S., Liu, M., Chiang, C., & Wang, J. (2013). Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. International Journal of Cardiology, 167(1), 41-50. https://doi.org/10.1016/j.ijcard.2011.11.086
Hambrecht, R., Gielen, S., Linke, A., Fiehn, E., Yu, J., Walther, C., Schoene, N., & Schuler, G. (2000). Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. JAMA, 283(23), 3095-3101. https://doi.org/10.1001/jama.283.23.3095
Haykowsky, M., Daniel, K., Bhella, P., Sarma, S., & Kitzman, D. (2016). Heart Failure: Exercise-Based Cardiac Rehabilitation: Who, When, and How Intense? The Canadian Journal of Cardiology, 32(10 Suppl 2), S382-S387. https://doi.org/10.1016/j.cjca.2016.06.001
Kim, H.-J., Oh, J.-K., Kim, C., Jee, H., Shin, K.-A., & Kim, Y.-J. (2013). Effects of six-week cardiac rehabilitation and exercise on adiponectin in patients with acute coronary syndrome. Kardiologia Polska, 71(9), 924-930. https://doi.org/10.5603/KP.2013.0227
Leon, A., Franklin, B., Costa, F., Balady, G., Berra, K. A., Stewart, K., Thompson, P., Williams, M., & Lauer, M. (2005). Cardiac rehabilitation and secondary prevention of coronary heart disease: An American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American association of Cardiovascular and Pulmonary Rehabilitation. Circulation, 111(3), 369-376. https://doi.org/10.1161/01.CIR.0000151788.08740.5C
Libby, P., & Theroux, P. (2005). Pathophysiology of Coronary Artery Disease. Circulation, 111(25), 3481-3488. https://doi.org/10.1161/CIRCULATIONAHA.105.537878
Lindmark, E., Diderholm, E., Wallentin, L., & Siegbahn, A. (2001). Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: Effects of an early invasive or noninvasive strategy. JAMA, 286(17), 2107-2113. https://doi.org/10.1001/jama.286.17.2107
Madjid, M., & Willerson, J. (2011). Inflammatory markers in coronary heart disease. British Medical Bulletin, 100(1), 23-38. https://doi.org/10.1093/bmb/ldr043
Marzolini, S., Oh, P., & Brooks, D. (2012). Effect of combined aerobic and resistance training versus aerobic training alone in individuals with coronary artery disease: A meta-analysis. European Journal of Preventive Cardiology, 19(1), 81-94. https://doi.org/10.1177/1741826710393197
Ministerio de Salud. (2017). Memoria Institucional-2016. Ministerio de Salud de Costa Rica. https://www.ministeriodesalud.go.cr/index.php/gestion-institucional/memoria-institucional-transparencia
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
Montero, D., Diaz, C., & Lundby, C. (2015). Endurance Training and VO2max: Role of Maximal Cardiac Output and Oxygen Extraction. Medicine and Science in Sports and Exercise, 47(10), 2024-2033. https://doi.org/10.1249/MSS.0000000000000640
Ohsuzu, F. (2004). The roles of cytokines, inflammation and immunity in vascular diseases. Journal of Atherosclerosis and Thrombosis, 11(6), 313-321. https://doi.org/10.5551/jat.11.313
Oldridge, N., Pakosh, M., & Grace, S. (2019). A systematic review of recent cardiac rehabilitation meta-analyses in patients with coronary heart disease or heart failure. Future Cardiology, 15(3), 227-249. https://doi.org/10.2217/fca-2018-0085
Organización Mundial de la Salud. (2018). The top 10 causes of death. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
Panagiotakos, D. B., Kokkinos, P., Manios, Y., & Pitsavos, C. (2004). Physical Activity and Markers of Inflammation and Thrombosis Related to Coronary Heart Disease. Preventive Cardiology, 7(4), 190-194. https://doi.org/10.1111/j.1520-037X.2004.03539.x
Pérez-Fernández, R., & Kaski, J. (2002). Interleucina-10 y enfermedad coronaria. Revista Española de Cardiología, 55(7), 738-750.
Pinto, A., Di Raimondo, D., Tuttolomondo, A., Buttà, C., Milio, G., & Licata, G. (2012). Effects of physical exercise on inflammatory markers of atherosclerosis. Current Pharmaceutical Design, 18(28), 4326-4349. https://doi.org/10.2174/138161212802481192
Ponikowski, P., Voors, A., Anker, S., Bueno, H., Cleland, J., Coats, A., Falk, V., González-Juanatey, J., Harjola, V., Jankowska, E., Jessup, M., Linde, C., Nihoyannopoulos, P., Parissis, J., Pieske, B., Riley, J., Rosano, G., Ruilope, L., Ruschitzka, F., … Van der Meer, P. (2016). 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure, 18(8), 891-975. https://doi.org/10.1002/ejhf.592
Reuben, D., Judd-Hamilton, L., Harris, T., & Seeman, T. (2003). The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. Journal of the American Geriatrics Society, 51(8), 1125-1130. https://doi.org/10.1046/j.1532-5415.2003.51380.x
Ridker, P., Hennekens, C., Buring, J., & Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. The New England Journal of Medicine, 342(12), 836-843. https://doi.org/10.1056/NEJM200003233421202
Roca-Rodríguez, M., Garrido-Sánchez, L., García-Almeida, J., Ruiz-Nava, J., Alcaide-Torres, J., Gómez-González, A., Montiel-Trujillo, A., & Tinahones-Madueño, F. (2015). Effects of exercise on inflammation in cardiac rehabilitation. Nutricion Hospitalaria, 31(6), 2633-2640. https://doi.org/10.3305/nh.2015.31.6.8868
Ross, R. (1999). Atherosclerosis—An inflammatory disease. New England Journal Medicine, 2(320), 115-126. https://doi.org/10.1056/NEJM199901143400207
Sandor, B., Nagy, A., Toth, A., Rabai, M., Mezey, B., Csatho, A., Czuriga, I., Toth, K., & Szabados, E. (2014). Effects of moderate aerobic exercise training on hemorheological and laboratory parameters in ischemic heart disease patients. PloS One, 9(10), e110751. https://doi.org/10.1371/journal.pone.0110751
Shin, Y.-O., Bae, J.-S., Lee, J.-B., Kim, J.-K., Kim, Y.-J., Kim, C., Ahn, J.-K., Bang, I.-K., Lee, B.-K., Othman, T., Min, Y.-K., & Yang, H.-M. (2006). Effect of cardiac rehabilitation and statin treatment on anti-HSP antibody titers in patients with coronary artery disease after percutaneous coronary intervention. International Heart Journal, 47(5), 671-682. https://doi.org/10.1536/ihj.47.671
Starkie, R., Ostrowski, S., Jauffred, S., Febbraio, M., & Pedersen, B. (2003). Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 17(8), 884-886. https://doi.org/10.1096/fj.02-0670fje
Stemme, S., Faber, B., Holm, J., Wiklund, O., Witztum, J., & Hansson, G. (1995). T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America, 92(9), 3893-3897. https://dx.doi.org/10.1073%2Fpnas.92.9.3893
Subiela, J., Torres, S., De Sanctis, J., & Hernández, N. (2018). Cardiorespiratory responses, nitric oxide production and inflammatory factors in patients with myocardial infarction after rehabilitation. Nitric Oxide: Biology and Chemistry, 76, 87-96. https://doi.org/10.1016/j.niox.2018.03.006
Swardfager, W., Herrmann, N., Cornish, S., Mazereeuw, G., Marzolini, S., Sham, L., & Lanctôt, K. L. (2012). Exercise intervention and inflammatory markers in coronary artery disease: A meta-analysis. American Heart Journal, 163(4), 666-676.e3. https://doi.org/10.1016/j.ahj.2011.12.017
Tabaei, S., Motallebnezhad, M., & Tabaee, S. S. (2020). Systematic review and meta-analysis of association of polymorphisms in inflammatory cytokine genes with coronary artery disease. Inflammation Research, 69(10), 1001-1013. https://doi.org/10.1007/s00011-020-01385-3
Taylor, R., Sagar, V., Davies, E., Briscoe, S., Coats, A. J. S., Dalal, H., Lough, F., Rees, K., & Singh, S. (2014). Exercise-based rehabilitation for heart failure. The Cochrane Database of Systematic Reviews, 4, CD003331. https://doi.org/10.1002/14651858.CD003331.pub4
Vanhees, L., Rauch, B., Piepoli, M., van Buuren, F., Takken, T., Börjesson, M., Bjarnason, B., Doherty, P., Dugmore, D., & Halle, M. (2012). Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular disease (Part III). European Journal of Preventive Cardiology, 19(6), 1333-1356. https://doi.org/10.1177/2047487312437063
Widlansky, M., Gokce, N., Keaney, J., & Vita, J. (2003). The clinical implications of endothelial dysfunction. Journal of the American College of Cardiology, 42(7), 1149-1160. https://doi.org/10.1016/s0735-1097(03)00994-x
Yancy, C., Jessup, M., Bozkurt, B., Butler, J., Casey, D., Colvin, M., Drazner, M., Filippatos, G., Fonarow, G., Givertz, M., Hollenberg, S., Lindenfeld, J., Masoudi, F., McBride, P., Peterson, P., Stevenson, L., & Westlake, C. (2017). 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Journal of Cardiac Failure, 23(8), 628-651. https://doi.org/10.1016/j.cardfail.2017.04.014
Publicado
Como Citar
Edição
Seção
Licença
Termos e condições gerais
MHSalud: Revista en Ciencias del Movimiento Humano y Salud da Universidad Nacional é licenciada sob uma Licença Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Costa Rica.
A revista está hospedada em repositórios de acesso aberto, como o Repositório Institucional da Universidade Nacional, o Repositório Kimuk da Costa Rica e a Referência.
A fonte editorial da revista deve ser reconhecida. Use para esse fim o identificador doi da publicação.
Política de autoarquivamento: A revista permite o autoarquivamento de artigos em sua versão revisada, editada e aprovada pelo Conselho Editorial da revista para que estejam disponíveis em Acesso Aberto através da Internet. Mais informações no link a seguir: https://v2.sherpa.ac.uk/id/publication/25815
